Cytotoxic T lymphocyte-assisted suicide. Caspase 3 activation is primarily the result of the direct action of granzyme B.

@article{Atkinson1998CytotoxicTL,
  title={Cytotoxic T lymphocyte-assisted suicide. Caspase 3 activation is primarily the result of the direct action of granzyme B.},
  author={Eric A. Atkinson and Michele Barry and Alison J. Darmon and Irene Shostak and Peter C. Turner and Richard W. Moyer and Robert Chris Bleackley},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 33},
  pages={21261-6}
}
Cytototoxic T lymphocyte-induced apoptosis can occur either through the directed exocytosis of granzyme B and perforin or via ligation of Fas. Both pathways involve the activation of a family of cysteine proteinases, the caspases, that cleave substrates at aspartic acid and are themselves activated by cleavage at internal aspartate residues. Fas recruits caspase 8, which initiates the death program through the subsequent activation of caspase 3. Granzyme B can process both caspase 8 and 3 in… CONTINUE READING
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