Cytotoxic T-lymphocyte antigen-4 gene polymorphisms and human T-cell lymphotrophic virus-1 infection: their associations with Hashimoto's thyroiditis in Japanese patients.

@article{Tomoyose2002CytotoxicTA,
  title={Cytotoxic T-lymphocyte antigen-4 gene polymorphisms and human T-cell lymphotrophic virus-1 infection: their associations with Hashimoto's thyroiditis in Japanese patients.},
  author={Takeaki Tomoyose and Ichiro Komiya and Masaki Takara and Kouichi Yabiku and Yoshino Kinjo and Yoshinori Shimajiri and Hiroyuki Yogi and Tsuyoshi Kouki and Masato Masuda and Nobuyuki Takasu},
  journal={Thyroid : official journal of the American Thyroid Association},
  year={2002},
  volume={12 8},
  pages={673-7}
}
Cytotoxic T-lymphocyte antigen-4 (CTLA-4) decreases the immune response of T cells by inactivating the signal that occurs with interaction between CD28 on T cells and B7 on antigen-presenting cells. Gene polymorphisms involving CTLA-4 promoter (-318 C/T), exon 1 (49 A/G), and exon 4 (microsatellite (AT)n) have been linked to Hashimoto's thyroiditis (HT) and other autoimmune diseases. HT also has a reported association with human T-cell lymphotrophic virus-1 (HTLV-1) infection. We investigated… CONTINUE READING
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