Cytotoxic T-lymphocyte antigen-4 A49G polymorphism is associated with susceptibility to and severity of alcoholic liver disease in Italian patients.

@article{Valenti2004CytotoxicTA,
  title={Cytotoxic T-lymphocyte antigen-4 A49G polymorphism is associated with susceptibility to and severity of alcoholic liver disease in Italian patients.},
  author={Luca Valenti and Tullia Maria De Feo and Anna Ludovica Fracanzani and Erika Fatta and Mario Salvagnini and Sarino Aric{\`o} and Giorgio Rossi and Gemino Fiorelli and Silvia Fargion},
  journal={Alcohol and alcoholism},
  year={2004},
  volume={39 4},
  pages={276-80}
}
AIMS To determine whether the functional A49G polymorphism of cytotoxic T-lymphocyte antigen-4 (CTLA-4), a T-cell surface molecule that modulates T-lymphocyte activation and influences the risk of developing alcohol-induced autoantibodies, plays a role in susceptibility to alcoholic liver disease (ALD) and influences disease severity in Italian alcohol abusers. METHODS One hundred and eighty-three patients with chronic ALD (61 cirrhosis), 115 end-stage HCV cirrhosis, 102 non-alcoholic fatty… CONTINUE READING