Cytotoxic T lymphocyte antigen–4 gene polymorphisms do not confer susceptibility to autoimmune hepatitis types 1 and 2 in Brazil

@article{Bittencourt2003CytotoxicTL,
  title={Cytotoxic T lymphocyte antigen–4 gene polymorphisms do not confer susceptibility to autoimmune hepatitis types 1 and 2 in Brazil},
  author={Paulo R L Bittencourt and Selma Aliotti Pal{\'a}cios and Eduardo L. R Cançado and Gilda Porta and Flair Jos{\'e} Carrilho and Ant{\^o}nio At{\'i}lio Laudanna and Jorge Agle Kalil and Anna Carla Goldberg},
  journal={American Journal of Gastroenterology},
  year={2003},
  volume={98},
  pages={1616-1620}
}
OBJECTIVES:Susceptibility to autoimmune hepatitis (AIH) has been linked to different HLA-DR antigens in distinct populations. Recently, an A–G polymorphism in exon 1 of the cytotoxic T lymphocyte antigen-4 (CTLA-4) gene was associated with predisposition to AIH type 1 (AIH-1) in white individuals in North America. This polymorphism has been associated with several other autoimmune diseases, presumably because of its effect in the expression of CTLA-4, an adhesion molecule that downregulates… CONTINUE READING
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MHC class II Table 3. Frequencies of CTLA-4 Genotypes in Patients With AIH-2 According to Clinical and Laboratory Parameters Clinical Features

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Autoimmune hepatitis types 1 and 2 in Brazil is not associated with polymorphisms in tumor necrosis factor polymorphisms

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