Cytotoxic T cells directed to tumor antigens not expressed on normal melanocytes dominate HLA-A2.1-restricted immune repertoire to melanoma.

@article{Anichini1996CytotoxicTC,
  title={Cytotoxic T cells directed to tumor antigens not expressed on normal melanocytes dominate HLA-A2.1-restricted immune repertoire to melanoma.},
  author={Andrea Anichini and Roberta Mortarini and Cristina Maccalli and Paola Squarcina and Katharina Fleischhauer and Luigi Mascheroni and Giorgio Parmiani},
  journal={Journal of immunology},
  year={1996},
  volume={156 1},
  pages={208-17}
}
To determine whether HLA-A21 restricted melanoma Ags exist that are not expressed on normal melanocytes, a panel of 478 T cell clones from six HLA-A21+ patients was selected for HLA-A2 restricted lysis of autologous tumor and then tested for differential recognition of HLA-A2.1+ melanomas and normal melanocytes. Four subsets of clones were identified in the panel of 107 HLA-A2-restricted CTL clones. CTL clones from three of the four subsets did not lyse melanocytes, but recognized fresh HLA-A2… CONTINUE READING