Cytotoxic T Lymphocyte Antigen 4 and CD28 Modulate Cell Surface Raft Expression in Their Regulation of T Cell Function

@article{Martn2001CytotoxicTL,
  title={Cytotoxic T Lymphocyte Antigen 4 and CD28 Modulate Cell Surface Raft Expression in Their Regulation of T Cell Function},
  author={Margarita Mart{\'i}n and Helga Schneider and Abdallah Azouz and Christopher E. Rudd},
  journal={The Journal of Experimental Medicine},
  year={2001},
  volume={194},
  pages={1675 - 1682}
}
Coreceptors CD28 and cytotoxic T lymphocyte antigen (CTLA)-4 have opposing effects on TcR/CD3 activation of T cells. While CD28 enhances and CTLA-4 inhibits activation, the underlying molecular basis of these effects has yet to be established. In this context, ganglioside and cholesterol enriched membrane microdomains (rafts, GEMs) serve as centers of… CONTINUE READING