Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Can Regulate Dendritic Cell–induced Activation and Cytotoxicity of CD8+ T Cells Independently of CD4+T Cell Help

@article{McCoy1999CytotoxicTL,
  title={Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4)  Can Regulate Dendritic Cell–induced Activation and  Cytotoxicity of CD8+ T Cells Independently of CD4+T Cell Help },
  author={Kathy D McCoy and Ian F Hermans and J. Henry Fraser and Graham Le Gros and Franca Ronchese},
  journal={The Journal of Experimental Medicine},
  year={1999},
  volume={189},
  pages={1157 - 1162}
}
The mechanisms that regulate the strength and duration of CD8(+) cytotoxic T cell activity determine the effectiveness of an antitumor immune response. To better understand the antitumor effects of anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) antibody treatment, we analyzed the effect of CTLA-4 signaling on CD8(+) T cells in vitro and in vivo. In vitro, cross-linking of CTLA-4 on purified CD8(+) T cells caused decreased proliferative responses to anti-CD3 stimulation and rapid loss… CONTINUE READING

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CTLA-4 ligation attenuates AP-1, NFAT and NFkB activity in activated T cells

J. H. Fraser, M. Rincon, K. D. McCoy, G. Le Gros
Eur. J. Immunol • 1999

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