Cytotoxic T Cells in PD-L1-Positive Malignant Pleural Mesotheliomas Are Counterbalanced by Distinct Immunosuppressive Factors.

@article{Awad2016CytotoxicTC,
  title={Cytotoxic T Cells in PD-L1-Positive Malignant Pleural Mesotheliomas Are Counterbalanced by Distinct Immunosuppressive Factors.},
  author={Mark M. Awad and Robert E. Jones and Hongye Liu and Patrick H Lizotte and Elena V. Ivanova and Meghana Kulkarni and Grit Sophie Herter-Sprie and Xiaoyun Liao and Abigail A Santos and Mark A Bittinger and Lauren Keogh and Syohei Koyama and Christina Almonte and Jessie M. English and Julianne Barlow and William G. Richards and David Allen Barbie and Adam J. Bass and Scott J Rodig and Frank Stephen Hodi and Kai W Wucherpfennig and Pasi Antero J{\"a}nne and Lynette M Sholl and Peter S. Hammerman and Kwok-kin Wong and Raphael Bueno},
  journal={Cancer immunology research},
  year={2016},
  volume={4 12},
  pages={1038-1048}
}
PD-L1 immunohistochemical staining does not always predict whether a cancer will respond to treatment with PD-1 inhibitors. We sought to characterize immune cell infiltrates and the expression of T-cell inhibitor markers in PD-L1-positive and PD-L1-negative malignant pleural mesothelioma samples. We developed a method for immune cell phenotyping using flow cytometry on solid tumors that have been dissociated into single-cell suspensions and applied this technique to analyze 43 resected… CONTINUE READING
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