Cytotoxic Sesquiterpene Lactones from Kauna lasiophthalma Griseb

@article{Maldonado2014CytotoxicSL,
  title={Cytotoxic Sesquiterpene Lactones from Kauna lasiophthalma Griseb},
  author={Eliana M Maldonado and Daniel Svensson and Stina Oredsson and Olov Sterner},
  journal={Scientia Pharmaceutica},
  year={2014},
  volume={82},
  pages={147 - 160}
}
Two new eudesmane derivatives (3 and 8) were isolated from the ethanol extract of the aerial parts of Kaunia lasiophthalma Griseb, together with 14 known eudesmane, germacrane, and guaiane sesquiterpenes, and four flavones. The structures and relative configurations of all the compounds were established by NMR spectroscopy and high-resolution mass spectrometry. The anticancer activity of sesquiterpenes 1, 3, 6–9, 11, 12, 14, and 16 was evaluated in vitro with the breast cancer cell lines… 

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References

SHOWING 1-10 OF 48 REFERENCES
A Further Guaianolide from Kaunia arbuscularis.
TLDR
Novanin, the thymol derivatives 1, 2 and 2 as well as the epoxide 3 are isolated, isolated from a Grosvenonia species and the 'HNMR signals of 2-H and 3-H are shifted.
Sesquiterpenes from the leaves of Laurus nobilis L.
Comparison of three cytotoxicity tests in the evaluation of the cytotoxicity of a spermine analogue on human breast cancer cell lines.
  • C. HolstS. Oredsson
  • Biology
    Toxicology in vitro : an international journal published in association with BIBRA
  • 2005
Allergenic sesquiterpene lactones from Eupatorium cannabinum L. and Kaunia rufescens (Lund ex de Candolle).
TLDR
A hitherto unknown alpha-methylene-gamma-butyrolactone, 3 beta-peroxyeucannabinolide, was isolated from Eupatorium cannabinum L., and this compound and eupatoriopicrin from the same plant showed a weak sensitizing capacity in guinea pigs.
Nmr Studies of Tatridin A and Some Related Sesquiterpene Lactones from Tanacetum vulgare
The aerial parts of specimens of Tanacetum vulgare growing in Germany yielded several sesquiterpene lactones with germacrane and eudesmane framework. The nmr spectra of tatridin A {1}, tatridin B
Structure of santamarine, a new sesquiterpene lactone
Studies Towards the Total Synthesis of Cycloaraneosene and Ophiobolin M: A General Strategy for the Construction of the 5−8 Bicyclic Ring System
The synthesis of the core unit of cycloaraneosene and ophiobolin M has been investigated, following a general strategy applicable to both 5-8 bicyclic systems. The synthetic strategy includes a
...
...