Cytotoxic Podophyllotoxin Type-Lignans from the Steam Bark of Bursera fagaroides var. fagaroides

  title={Cytotoxic Podophyllotoxin Type-Lignans from the Steam Bark of Bursera fagaroides var. fagaroides},
  author={Andr{\'e}s M. Rojas-Sep{\'u}lveda and Mario A Mendieta-Serrano and Mayra Y. Ant{\'u}nez Mojica and Enrique Salas-Vidal and Silvia Marquina and Mar{\'i}a Luisa Villarreal and Ana Mar{\'i}a Puebla and Jorge Isaac Delgado and Laura Alvarez},
  pages={9506 - 9519}
The hydroalcoholic extract of the steam bark of B. fagaroides var. fagaroides displayed potent cytotoxic activity against four cancer cell lines, namely KB (ED50 = 9.6 × 10−2 μg/mL), PC-3 (ED50 = 2.5 × 10−1 μg/mL), MCF-7 (ED50 = 6.6 μg/mL), and HF-6 (ED50 = 7.1 × 10−3 μg/mL). This extract also showed anti-tumour activity when assayed on mice inoculated with L5178Y lymphoma cells. Bioactivity-directed isolation of this extract, afforded seven podophyllotoxin-type lignans identified as… 

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