Cytotoxic Plakortides from the Brazilian Marine Sponge Plakortis angulospiculatus.

@article{Santos2015CytotoxicPF,
  title={Cytotoxic Plakortides from the Brazilian Marine Sponge Plakortis angulospiculatus.},
  author={Evelyne Alves Santos and Amanda L Quintela and Elthon Gois Ferreira and Thiciana da S Sousa and Francisco das Chagas L Pinto and Eduardo Hajdu and Mariana Comanucci Silva Carvalho and Sula Salani and Danilo Damasceno Rocha and Diego Veras Wilke and Maria da Conceiç{\~a}o de Menezes Torres and Paula Christine Jimenez and Edilberto Rocha da Silveira and James J La Clair and Ot{\'i}lia Deusd{\^e}nia Loiola Pessoa and Let{\'i}cia V Costa-Lotufo},
  journal={Journal of natural products},
  year={2015},
  volume={78 5},
  pages={996-1004}
}
Three new plakortides, 7,8-dihydroplakortide E (1), 2, and 10, along with known natural products 3, 4, spongosoritin A (5), 6-8, and plakortide P (9), were isolated from Brazilian specimens of Plakortis angulospiculatus. Compounds 2, 3, 5, and 7-9 displayed cytotoxic activities with IC50 values ranging from 0.2 to 10 μM. Compounds that contained a dihydrofuran ring were generally less active and displayed time dependence in their activity. The activities of compounds 2 and 7-9, carboxylic acids… CONTINUE READING
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