Cytotoxic Effect of Brain Macrophages on Developing Neurons.

  title={Cytotoxic Effect of Brain Macrophages on Developing Neurons.},
  author={Clotilde Th{\'e}ry and Brigitte Chamak and Michel Mallat},
  journal={The European journal of neuroscience},
  volume={3 11},
Brain macrophages are transiently present in different regions of the central nervous system during development or in the course of tissue remodelling following various types of injuries. To investigate the influence of these phagocytes on neuronal growth and survival, brain macrophages stemming from the cerebral cortex of rat embryos were added to neuronal primary cultures. A neurotoxic effect of brain macrophages was demonstrated by the reduction of the number of neurons bearing neurites… CONTINUE READING
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