Cytotoxic Cardenolide and Sterols from Calotropis Gigantea

@article{Jacinto2011CytotoxicCA,
  title={Cytotoxic Cardenolide and Sterols from Calotropis Gigantea},
  author={S. Jacinto and Eunice Chun and A. Montuno and C. Shen and D. L. Espineli and C. Ragasa},
  journal={Natural Product Communications},
  year={2011},
  volume={6}
}
The dichloromethane extract from the leaves of Calotropis gigantea Linn. was strongly cytotoxic against non-small cell lung carcinoma (A549), colon carcinoma (HCT 116) and hepatocellular carcinoma (Hep G2), and non toxic to Chinese hamster ovary (AA8). The extract afforded uscharin (1), 3,5,8-trihydroxy-24-methylcholest-6,22-diene (2), a mixture of (24R)-3β-hydroxy-24-ethylcholest-5-en-7-one (3a) and 6β-hydroxy-24-ethylcholest-4,22-dien-3-one (3b), and another mixture of (24R)-24-ethylcholest-4… Expand
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