Cytotoxic Capacity of SIV-Specific CD8+ T Cells against Primary Autologous Targets Correlates with Immune Control in SIV-Infected Rhesus Macaques

@inproceedings{Mendoza2013CytotoxicCO,
  title={Cytotoxic Capacity of SIV-Specific CD8+ T Cells against Primary Autologous Targets Correlates with Immune Control in SIV-Infected Rhesus Macaques},
  author={D Eliseo A Mendoza and Stephen A Migueles and Julia E. Rood and Bennett A. Peterson and Sarah A. Johnson and Nicole A Doria-Rose and Douglas Schneider and Eva G Rakasz and Matthew T Trivett and Charles Mac Trubey and Vicky J Coalter and Claire W. Hallahan and David L Watkins and Genoveffa Franchini and Jeffrey D Lifson and Mark Connors},
  booktitle={PLoS pathogens},
  year={2013}
}
Although the study of non-human primates has resulted in important advances for understanding HIV-specific immunity, a clear correlate of immune control over simian immunodeficiency virus (SIV) replication has not been found to date. In this study, CD8(+) T-cell cytotoxic capacity was examined to determine whether this function is a correlate of immune control in the rhesus macaque (RM) SIV infection model as has been suggested in chronic HIV infection. SIVmac251-infected human reverse… CONTINUE READING
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