Cytotoxic CD8+ T cells stimulate hematopoietic progenitors by promoting cytokine release from bone marrow mesenchymal stromal cells.

Abstract

Cytotoxic CD8(+) T cells (CTLs) play a major role in host defense against intracellular pathogens, but a complete clearance of pathogens and return to homeostasis requires the regulated interplay of the innate and acquired immune systems. Here, we show that interferon γ (IFNγ) secreted by effector CTLs stimulates hematopoiesis at the level of early… (More)
DOI: 10.1016/j.stem.2014.01.002

Topics

7 Figures and Tables

Cite this paper

@article{Schrch2014CytotoxicCT, title={Cytotoxic CD8+ T cells stimulate hematopoietic progenitors by promoting cytokine release from bone marrow mesenchymal stromal cells.}, author={Christian M Sch{\"{u}rch and Carsten Riether and Adrian F Ochsenbein}, journal={Cell stem cell}, year={2014}, volume={14 4}, pages={460-72} }