Cytotoxic CD8+ T cell-neuron interactions: perforin-dependent electrical silencing precedes but is not causally linked to neuronal cell death.

@article{Meuth2009CytotoxicCT,
  title={Cytotoxic CD8+ T cell-neuron interactions: perforin-dependent electrical silencing precedes but is not causally linked to neuronal cell death.},
  author={Sven G. Meuth and Alexander M. Herrmann and Ole Jan Simon and Volker Siffrin and Nico Melzer and Stefan Bittner and Patrick Meuth and Harald F Langer and Stefan Hallermann and Nadia Boldakowa and Josephine Herz and Thomas Munsch and Peter Landgraf and Orhan Aktas and Manfred Heckmann and Volkmar Lessmann and Thomas Budde and Bernd C. Kieseier and Frauke Zipp and Heinz Wiendl},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2009},
  volume={29 49},
  pages={15397-409}
}
Cytotoxic CD8(+) T cells are considered important effector cells contributing to neuronal damage in inflammatory and degenerative CNS disorders. Using time-lapse video microscopy and two-photon imaging in combination with whole-cell patch-clamp recordings, we here show that major histocompatibility class I (MHC I)-restricted neuronal antigen presentation and T cell receptor specificity determine CD8(+) T-cell locomotion and neuronal damage in culture and hippocampal brain slices. Two separate… CONTINUE READING
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