Cytotoxic CD4 T cells in viral hepatitis.

  title={Cytotoxic CD4 T cells in viral hepatitis.},
  author={Nuray Aslan and Cihan Yurdaydin and J Wiegand and T Greten and Ayse Ciner and Manuela F Meyer and Hans Heiken and Birger Kuhlmann and Thorsten Kaiser and Hakan Bozkaya and Hans L Tillmann and Abdurrahman Mithat Bozdayi and Michael P. Manns and Heiner Wedemeyer},
  journal={Journal of viral hepatitis},
  volume={13 8},
CD4+ T cells are thought to contribute to antiviral immune responses by secretion of cytokines thereby providing help to CD8+ T and B cells. However, perforin-positive cytotoxic CD4+ T cells have been described in human immunodeficiency virus-positive patients suggesting a role not only of CD8+ but also of CD4+ T cells for killing virus-infected cells. We investigated 76 patients with viral hepatitis [15 hepatitis B virus (HBV), 22 HBV/hepatitis D virus and 17 hepatitis C virus (HCV)] for… CONTINUE READING


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