Cytotoxic CD4+ T cell responses to EBV contrast with CD8 responses in breadth of lytic cycle antigen choice and in lytic cycle recognition.

@article{Long2011CytotoxicCT,
  title={Cytotoxic CD4+ T cell responses to EBV contrast with CD8 responses in breadth of lytic cycle antigen choice and in lytic cycle recognition.},
  author={Heather M. Long and Alison M. Leese and Odette Louise Chagoury and Shawn R. Connerty and Jared Quarcoopome and Laura L. Quinn and Claire D Shannon-Lowe and A. B. Page Rickinson},
  journal={Journal of immunology},
  year={2011},
  volume={187 1},
  pages={
          92-101
        }
}
EBV, a B lymphotropic herpesvirus, encodes two immediate early (IE)-, >30 early (E)-, and >30 late (L)-phase proteins during its replication (lytic) cycle. Despite this, lytic Ag-induced CD8 responses are strongly skewed toward IE and a few E proteins only, all expressed before HLA I presentation is blocked in lytically infected cells. For comparison, we examined CD4(+) T cell responses to eight IE, E, or L proteins, screening 14 virus-immune donors to overlapping peptide pools in IFN-γ ELISPOT… CONTINUE READING
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