Cytotoxic Activity of New Phenolic Compounds from Vietnamese Caesalpinia sappan

@article{Hng2013CytotoxicAO,
  title={Cytotoxic Activity of New Phenolic Compounds from Vietnamese Caesalpinia sappan},
  author={Trần Mạnh H{\`u}ng and Nguyễn Xu{\^a}n Hải and Nguyễn Trung Nh{\^a}n and Ton That Quang and Tran Le Quan and To Dao Cuong and Nguyen Hai Dang and Nguyen Tien Dat},
  journal={Bioscience, Biotechnology, and Biochemistry},
  year={2013},
  volume={77},
  pages={2378 - 2382}
}
Two new phenolic compounds, caesalpiniaphenols G–H (1 and 2), were isolated from Vietnamese Caesalpinia sappan heartwood. The chemical structures were established mainly by extensive spectroscopic studies and chemical evidence. Compounds 1 and 2 showed potent inhibitory activity against HL-60 cancer cell lines with respective IC50 values of 16.7 and 22.5 µg/mL. Treating HL-60 cells with various concentrations of 1 resulted in growth inhibition and the induction of apoptosis. 
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Biancaea sappan (L.) Tod. Fabaceae
Biancaea sappan (L.) Tod. Fabaceae
Lignum Sappan – Sumu

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