Cytotoxic Activity of Extracts from Plants of Central Argentina on Sensitive and Multidrug-Resistant Leukemia Cells: Isolation of an Active Principle from Gaillardia megapotamica

@inproceedings{Gonzlez2018CytotoxicAO,
  title={Cytotoxic Activity of Extracts from Plants of Central Argentina on Sensitive and Multidrug-Resistant Leukemia Cells: Isolation of an Active Principle from Gaillardia megapotamica},
  author={Mar{\'i}a Laura Gonz{\'a}lez and Mariana Bel{\'e}n Joray and Jer{\'o}nimo Laiolo and Mar{\'i}a In{\'e}s Crespo and Sara Mar{\'i}a Palacios and Gustavo Miguel Ruiz and Mar{\'i}a Cecilia Carpinella},
  booktitle={Evidence-based complementary and alternative medicine : eCAM},
  year={2018}
}
Plants are a significant reservoir of cytotoxic agents, including compounds with the ability to interfere with multidrug-resistant (MDR) cells. With the aim of finding promising candidates for chemotherapy, 91 native and naturalized plants collected from the central region of Argentina were screened for their cytotoxic effect toward sensitive and MDR P-glycoprotein (P-gp) overexpressing human leukemia cells by means of MTT assays. The ethanol extracts obtained from Aldama tucumanensis, Ambrosia… CONTINUE READING
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