Cytotoxic Activity of Chalcones Isolated from Lonchocarpus Sericeus (Pocr.) Kunth

@article{Cunha2003CytotoxicAO,
  title={Cytotoxic Activity of Chalcones Isolated from Lonchocarpus Sericeus (Pocr.) Kunth},
  author={G. M. Cunha and J. Fontenele and H. V. Nobre J{\'u}nior and Francisco D. M. de Sousa and E. Silveira and N. Nogueira and M. O. de Moraes and G. Viana and L. Costa-Lotufo},
  journal={Phytotherapy Research},
  year={2003},
  volume={17}
}
In the present study, it was demonstrated that the hexanic extract obtained from the roots of Lonchocarpus sericeus and one of its major components, derricin, but not lonchocarpin, show cytotoxic activity to fertilized sea urchin eggs. Both inhibited the first cleavage of sea urchin eggs in a dose‐dependent manner with an IC50 of 30.4 (26.2–35.3) μg/mL for the crude extract and 51.2 (42.1–62.3) μg/mL for derricin (n = 6, in both cases). Furthermore, the hexanic extract of L. sericeus, and the… Expand
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