Cytotoxic, genotoxic and oxidative stress induced by 1,4-naphthoquinone in B16F1 melanoma tumor cells.

@article{Kumar2009CytotoxicGA,
  title={Cytotoxic, genotoxic and oxidative stress induced by 1,4-naphthoquinone in B16F1 melanoma tumor cells.},
  author={Mandala Rayabandla Sunil Kumar and Kiran Aithal and Bhuvanagiri Nageshwar Rao and Nayanabhirama Udupa and Bola Sadashiva Satish Rao},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2009},
  volume={23 2},
  pages={242-50}
}
Quinones have diverse pharmacological properties including antibacterial, antifungal, antiviral, anti-inflammatory, antipyretic and anticancer activity. The cytotoxic potential of 1,4-naphthoquinone (NQ14) was studied against B16F1 melanoma cells grown in vitro. NQ14 treatment resulted in a concentration-dependent cytotoxicity as indicated by MTT assay and lactate dehydrogenase leakage assay. Depletion in cellular glutathione levels after 1h incubation with NQ14 correlated with the… CONTINUE READING

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Quinones have diverse pharmacological properties including antibacterial , antifungal , antiviral , anti - inflammatory , antipyretic and anticancer activity .
Quinones have diverse pharmacological properties including antibacterial , antifungal , antiviral , anti - inflammatory , antipyretic and anticancer activity .
Quinones have diverse pharmacological properties including antibacterial , antifungal , antiviral , anti - inflammatory , antipyretic and anticancer activity .
Quinones have diverse pharmacological properties including antibacterial , antifungal , antiviral , anti - inflammatory , antipyretic and anticancer activity .
Quinones have diverse pharmacological properties including antibacterial , antifungal , antiviral , anti - inflammatory , antipyretic and anticancer activity .
Quinones have diverse pharmacological properties including antibacterial , antifungal , antiviral , anti - inflammatory , antipyretic and anticancer activity .
Quinones have diverse pharmacological properties including antibacterial , antifungal , antiviral , anti - inflammatory , antipyretic and anticancer activity .
Quinones have diverse pharmacological properties including antibacterial , antifungal , antiviral , anti - inflammatory , antipyretic and anticancer activity .
Quinones have diverse pharmacological properties including antibacterial , antifungal , antiviral , anti - inflammatory , antipyretic and anticancer activity .
Quinones have diverse pharmacological properties including antibacterial , antifungal , antiviral , anti - inflammatory , antipyretic and anticancer activity .
Quinones have diverse pharmacological properties including antibacterial , antifungal , antiviral , anti - inflammatory , antipyretic and anticancer activity .
Quinones have diverse pharmacological properties including antibacterial , antifungal , antiviral , anti - inflammatory , antipyretic and anticancer activity .
Quinones have diverse pharmacological properties including antibacterial , antifungal , antiviral , anti - inflammatory , antipyretic and anticancer activity .
Quinones have diverse pharmacological properties including antibacterial , antifungal , antiviral , anti - inflammatory , antipyretic and anticancer activity .
Further , a dose - dependent decrease in the clonogenic cell survival indicated the potential of NQ14 to inhibit cell proliferation contributing to cell death .
Further , a dose - dependent decrease in the clonogenic cell survival indicated the potential of NQ14 to inhibit cell proliferation contributing to cell death .
The cell death after NQ14 treatment may be attributed to apoptosis as seen in DNA ladder pattern along with necrosis as indicated in flow cytometric analysis of Annexin V / PI stained cells .
The cell death after NQ14 treatment may be attributed to apoptosis as seen in DNA ladder pattern along with necrosis as indicated in flow cytometric analysis of Annexin V / PI stained cells .
The cell death after NQ14 treatment may be attributed to apoptosis as seen in DNA ladder pattern along with necrosis as indicated in flow cytometric analysis of Annexin V / PI stained cells .
The cell death after NQ14 treatment may be attributed to apoptosis as seen in DNA ladder pattern along with necrosis as indicated in flow cytometric analysis of Annexin V / PI stained cells .
The cell death after NQ14 treatment may be attributed to apoptosis as seen in DNA ladder pattern along with necrosis as indicated in flow cytometric analysis of Annexin V / PI stained cells .
The frequency of micronucleated binucleate cells increased with increasing doses of NQ14 with a corresponding decrease in the cytokinesis block proliferation index indicating the drug induced genotoxicity and cell division delay .
The frequency of micronucleated binucleate cells increased with increasing doses of NQ14 with a corresponding decrease in the cytokinesis block proliferation index indicating the drug induced genotoxicity and cell division delay .
Cell divisionProcess includes biological processCytokinesis
The frequency of micronucleated binucleate cells increased with increasing doses of NQ14 with a corresponding decrease in the cytokinesis block proliferation index indicating the drug induced genotoxicity and cell division delay .
The frequency of micronucleated binucleate cells increased with increasing doses of NQ14 with a corresponding decrease in the cytokinesis block proliferation index indicating the drug induced genotoxicity and cell division delay .
The cell death after NQ14 treatment may be attributed to apoptosis as seen in DNA ladder pattern along with necrosis as indicated in flow cytometric analysis of Annexin V / PI stained cells .
The cell death after NQ14 treatment may be attributed to apoptosis as seen in DNA ladder pattern along with necrosis as indicated in flow cytometric analysis of Annexin V / PI stained cells .
The cell death after NQ14 treatment may be attributed to apoptosis as seen in DNA ladder pattern along with necrosis as indicated in flow cytometric analysis of Annexin V / PI stained cells .
The cell death after NQ14 treatment may be attributed to apoptosis as seen in DNA ladder pattern along with necrosis as indicated in flow cytometric analysis of Annexin V / PI stained cells .
The cell death after NQ14 treatment may be attributed to apoptosis as seen in DNA ladder pattern along with necrosis as indicated in flow cytometric analysis of Annexin V / PI stained cells .
The cell death after NQ14 treatment may be attributed to apoptosis as seen in DNA ladder pattern along with necrosis as indicated in flow cytometric analysis of Annexin V / PI stained cells .
The cell death after NQ14 treatment may be attributed to apoptosis as seen in DNA ladder pattern along with necrosis as indicated in flow cytometric analysis of Annexin V / PI stained cells .
The cell death after NQ14 treatment may be attributed to apoptosis as seen in DNA ladder pattern along with necrosis as indicated in flow cytometric analysis of Annexin V / PI stained cells .
The cell death after NQ14 treatment may be attributed to apoptosis as seen in DNA ladder pattern along with necrosis as indicated in flow cytometric analysis of Annexin V / PI stained cells .
The cell death after NQ14 treatment may be attributed to apoptosis as seen in DNA ladder pattern along with necrosis as indicated in flow cytometric analysis of Annexin V / PI stained cells .
The cell death after NQ14 treatment may be attributed to apoptosis as seen in DNA ladder pattern along with necrosis as indicated in flow cytometric analysis of Annexin V / PI stained cells .
The cell death after NQ14 treatment may be attributed to apoptosis as seen in DNA ladder pattern along with necrosis as indicated in flow cytometric analysis of Annexin V / PI stained cells .
The cell death after NQ14 treatment may be attributed to apoptosis as seen in DNA ladder pattern along with necrosis as indicated in flow cytometric analysis of Annexin V / PI stained cells .
The cell death after NQ14 treatment may be attributed to apoptosis as seen in DNA ladder pattern along with necrosis as indicated in flow cytometric analysis of Annexin V / PI stained cells .
The cell death after NQ14 treatment may be attributed to apoptosis as seen in DNA ladder pattern along with necrosis as indicated in flow cytometric analysis of Annexin V / PI stained cells .
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