Cytotoxic, allergic and genotoxic activity of a nickel-titanium alloy.

  title={Cytotoxic, allergic and genotoxic activity of a nickel-titanium alloy.},
  author={D. J. Wever and Albert G. Veldhuizen and Michel M. Sanders and J. M. Schakenraad and James R van Horn},
  volume={18 16},
The nearly equiatomic nickel-titanium (NiTi) alloy is known for its shape memory properties. These properties can be put to excellent use in various biomedical applications, such as wires for orthodontic tooth alignment and osteosynthesis staples. The aim of this study was to evaluate the short-term biological safety of the NiTi alloy. We carried out an end-point dilution minimal essential medium (MEM) extract cytotoxicity test, a guinea-pig sensitization test and two genotoxicity tests: the… CONTINUE READING


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