Cytostatic gene therapy for vascular proliferative disorders with a constitutively active form of the retinoblastoma gene product.

@article{Chang1995CytostaticGT,
  title={Cytostatic gene therapy for vascular proliferative disorders with a constitutively active form of the retinoblastoma gene product.},
  author={Myung Woong Chang and Eliav Barr and Jon Seltzer and Y. Q. Jiang and Gary J. Nabel and Elizabeth G. Nabel and Michael S. Parmacek and Jeffrey M. Leiden},
  journal={Science},
  year={1995},
  volume={267 5197},
  pages={518-22}
}
Vascular smooth muscle cell (SMC) proliferation in response to injury is an important etiologic factor in vascular proliferative disorders such as atherosclerosis and restenosis after balloon angioplasty. The retinoblastoma gene product (Rb) is present in the unphosphorylated and active form in quiescent primary arterial SMCs, but is rapidly inactivated by… CONTINUE READING