Cytosolic thiol switches regulating basic cellular functions: GAPDH as an information hub?

@article{Hildebrandt2015CytosolicTS,
  title={Cytosolic thiol switches regulating basic cellular functions: GAPDH as an information hub?},
  author={Thomas H. Hildebrandt and Johannes Knuesting and Carsten Berndt and Bruce A. Morgan and Renate Scheibe},
  journal={Biological chemistry},
  year={2015},
  volume={396 5},
  pages={523-37}
}
Cytosolic glyceraldehyde 3-phosphate dehydrogenase (GAPDH, E.C. 1.2.1.12) is present in all organisms and catalyzes the oxidation of triose phosphate during glycolysis. GAPDH is one of the most prominent cellular targets of oxidative modifications when reactive oxygen and nitrogen species are formed during metabolism and under stress conditions. GAPDH harbors a strictly conserved catalytic cysteine, which is susceptible to a variety of thiol modifications, including S-sulfenylation, S… CONTINUE READING