Cytosolic redox components regulate protein homeostasis via additional localisation in the mitochondrial intermembrane space

@inproceedings{CardenasRodriguez2017CytosolicRC,
  title={Cytosolic redox components regulate protein homeostasis via additional localisation in the mitochondrial intermembrane space},
  author={Mauricio Cardenas‐Rodriguez and Kostas Tokatlidis},
  booktitle={FEBS letters},
  year={2017}
}
Oxidative protein folding is confined to the bacterial periplasm, endoplasmic reticulum and the mitochondrial intermembrane space. Maintaining a redox balance requires the presence of reductive pathways. The major thiol-reducing pathways engage the thioredoxin and the glutaredoxin systems which are involved in removal of oxidants, protein proofreading and folding. Alterations in redox balance likely affect the flux of these redox pathways and are related to ageing and diseases such as… CONTINUE READING