Cytosolic protein tyrosine phosphatase-epsilon is a negative regulator of insulin signaling in skeletal muscle.

@article{AgaMizrachi2008CytosolicPT,
  title={Cytosolic protein tyrosine phosphatase-epsilon is a negative regulator of insulin signaling in skeletal muscle.},
  author={Shlomit Aga-Mizrachi and Tamar Brutman-Barazani and Avraham I Jacob and A. P. Bak and Ari Elson and Sanford R. Sampson},
  journal={Endocrinology},
  year={2008},
  volume={149 2},
  pages={
          605-14
        }
}
Whereas positive regulatory events triggered by insulin binding to insulin receptor (IR) have been well documented, the mechanism by which the activated IR is returned to the basal status is not completely understood. Recently studies focused on the involvement of protein tyrosine phosphatases (PTPs) and how they might influence IR signaling. In this study, we examined the possibility that cytosolic PTPepsilon (cytPTPepsilon) is involved in IR signaling. Studies were performed on L6 skeletal… CONTINUE READING

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