Cytosolic phospholipase A2 and lipoxygenase are involved in cell cycle progression in neuroblastoma cells

@article{Rossum2002CytosolicPA,
  title={Cytosolic phospholipase A2 and lipoxygenase are involved in cell cycle progression in neuroblastoma cells},
  author={G. S. A. T. van Rossum and J. J. M. Bijvelt and H. van den Bosch and Arie J. Verkleij and Johannes Boonstra},
  journal={Cellular and Molecular Life Sciences CMLS},
  year={2002},
  volume={59},
  pages={181-188}
}
Arachidonic acid has been implicated in regulating cellular proliferation, and is preferentially released by the 85-kDa cytosolic phospholipase A2 (cPLA2). Recently, we demonstrated that cPLA2 is activated at distinct periods during the ongoing cell cycle of neuroblastoma cells. The purpose of the present study was to establish the role of these cPLA2 activity peaks in cell cycle progression. Inhibition of cPLA2 activity with arachidonyl trifluoromethylketone (ATK) in early G1 phase reduced DNA… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 50 references

15 S - hydroxyeicosate - traenoic acid activates peroxisome proliferator - activated receptor gamma and inhibits proliferation in PC 3 prostate carcinoma cells

  • B. ShappellS., A. GuptaR., S. Manning, R. Whitehead, E. BoeglinW., C. Schneider
  • Cancer Res .
  • 2001

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