Cytosolic phospholipase A(2), lipoxygenase metabolites, and reactive oxygen species.

@article{Kim2008CytosolicPA,
  title={Cytosolic phospholipase A(2), lipoxygenase metabolites, and reactive oxygen species.},
  author={Cheolmin Kim and Joo-Young Kim and Jae-Hong Kim},
  journal={BMB reports},
  year={2008},
  volume={41 8},
  pages={555-9}
}
Reactive oxygen species (ROS) are generated in mammalian cells via both enzymatic and non-enzymatic mechanisms. Although certain ROS production pathways are required for the performance of specific physiological functions, excessive ROS generation is harmful, and has been implicated in the pathogenesis of a number of diseases. Among the ROS-producing enzymes, NADPH oxidase is widely distributed among mammalian cells, and is a crucial source of ROS for physiological and pathological processes… CONTINUE READING