Cytosolic pH is a second messenger for glucose and regulates the PKA pathway through V-ATPase.

@article{Dechant2010CytosolicPI,
  title={Cytosolic pH is a second messenger for glucose and regulates the PKA pathway through V-ATPase.},
  author={Reinhard Dechant and Matteo Binda and Sung Sik Lee and Serge Pelet and Joris Winderickx and Matthias Peter},
  journal={The EMBO journal},
  year={2010},
  volume={29 15},
  pages={2515-26}
}
Glucose is the preferred carbon source for most cell types and a major determinant of cell growth. In yeast and certain mammalian cells, glucose activates the cAMP-dependent protein kinase A (PKA), but the mechanisms of PKA activation remain unknown. Here, we identify cytosolic pH as a second messenger for glucose that mediates activation of the PKA pathway in yeast. We find that cytosolic pH is rapidly and reversibly regulated by glucose metabolism and identify the vacuolar ATPase (V-ATPase… CONTINUE READING
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