Cytosolic nucleic acid sensors and innate immune regulation.

@article{Ori2017CytosolicNA,
  title={Cytosolic nucleic acid sensors and innate immune regulation.},
  author={Daisuke Ori and Motoya Murase and Taro Kawai},
  journal={International reviews of immunology},
  year={2017},
  volume={36 2},
  pages={74-88}
}
During viral and bacterial infections, pathogen-derived cytosolic nucleic acids are recognized by the intracellular RNA sensors retinoic acid-inducible gene I and melanoma-differentiated gene 5 and intracellular DNA sensors, including cyclic-di-GMP-AMP synthase, absent in melanoma 2, interferon (IFN)-gamma inducible protein 16, polymerase III, and so on. Binding of intracellular nucleic acids to these sensors activates downstream signaling cascades, resulting in the production of type I IFNs… CONTINUE READING
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