Cytosolic monothiol glutaredoxins function in intracellular iron sensing and trafficking via their bound iron-sulfur cluster.

@article{Mhlenhoff2010CytosolicMG,
  title={Cytosolic monothiol glutaredoxins function in intracellular iron sensing and trafficking via their bound iron-sulfur cluster.},
  author={Ulrich M{\"u}hlenhoff and Sabine Molik and Jos{\'e} Rodrigo Godoy and Marta A. Uzarska and Nadine Richter and A. Peter Seubert and Yan Zhang and JoAnne Stubbe and Fabien Pierrel and Enrique Montero Herrero and Christopher Horst Lillig and Roland Lill},
  journal={Cell metabolism},
  year={2010},
  volume={12 4},
  pages={
          373-385
        }
}
Iron is an essential nutrient for cells. It is unknown how iron, after its import into the cytosol, is specifically delivered to iron-dependent processes in various cellular compartments. Here, we identify an essential function of the conserved cytosolic monothiol glutaredoxins Grx3 and Grx4 in intracellular iron trafficking and sensing. Depletion of Grx3/4 specifically impaired all iron-requiring reactions in the cytosol, mitochondria, and nucleus, including the synthesis of Fe/S clusters… CONTINUE READING
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