Cytosolic chaperonin is up-regulated during cell growth. Preferential expression and binding to tubulin at G(1)/S transition through early S phase.

@article{Yokota1999CytosolicCI,
  title={Cytosolic chaperonin is up-regulated during cell growth. Preferential expression and binding to tubulin at G(1)/S transition through early S phase.},
  author={S I Yokota and Hideki Yanagi and Takashi Yura and Hiroshi Kubota},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 52},
  pages={37070-8}
}
The chaperonin containing t-complex polypeptide 1 (CCT) is a heterooligomeric molecular chaperone assisting in the folding of actin, tubulin, and other cytosolic proteins. The expression levels of CCT subunits varied among seven mouse cell lines tested but showed a close correlation with growth rate. Both the CCT protein and mRNA levels in the human… CONTINUE READING