Cytosolic calcium staircase in ventricular myocytes isolated from guinea pigs and rats.

@article{Hattori1991CytosolicCS,
  title={Cytosolic calcium staircase in ventricular myocytes isolated from guinea pigs and rats.},
  author={Yuiehi Hattori and Junji Toyama and Itsuo Kodama},
  journal={Cardiovascular research},
  year={1991},
  volume={25 8},
  pages={622-9}
}
STUDY OBJECTIVE The aim was to study intracellular calcium dynamics underlying positive or negative tension staircase of mammalian hearts. DESIGN Changes in cytosolic calcium concentration [( Ca2+]i) in single ventricular myocytes were investigated using a Ca2+ indicator, fura-2. Beat to beat alterations in fura-2 fluorescence and cell edge movement on resumption of stimulation were recorded on video tape, and analysed by a computer based image processing system. EXPERIMENTAL MATERIAL… CONTINUE READING