Cytosolic calcium staircase in cultured myocardial cells.

@article{Lee1987CytosolicCS,
  title={Cytosolic calcium staircase in cultured myocardial cells.},
  author={H C Lee and William T. Clusin},
  journal={Circulation research},
  year={1987},
  volume={61 6},
  pages={934-9}
}
To elucidate the mechanism of the tension staircase, chick embryonic myocardial cell aggregates were loaded with the fluorescent cytosolic calcium indicator, indo 1. Fluctuations in indo 1 fluorescence were compared with recordings of cell edge movement during spontaneous beating and during stimulation by intracellular current pulses. Indo 1-loaded aggregates exhibit fluorescence transients during each transmembrane action potential. The rising phase of the transients is rapid, but the decaying… CONTINUE READING

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Changes in [Ca]; during spontaneous contraction and zero-[Na]o-induced contracture in cultured ventricular cells detected with indo 1 (abstract)

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Observation of calcium transients in isolated cardiac myocytes using indo-1 (abstract)

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