Cytosolic calcium in platelets of spontaneously hypertensive rats.

  title={Cytosolic calcium in platelets of spontaneously hypertensive rats.},
  author={Reuven Zimlichman and David S Goldstein and Shulamit Zimlichman and Harry R. Keiser},
  journal={Journal of hypertension},
  volume={4 3},
To test the hypothesis that an abnormality of the intracellular concentration of ionized calcium, [Ca2+]i, is associated with high blood pressure, we measured [Ca2+]i in the platelets of spontaneously hypertensive (SHR) and Wistar-Kyoto control (WKY) rats using the Quin 2 technique after separation of the platelets in calcium-free medium, during calcium repletion, and upon exposure to agonists which increase platelet [Ca2+]i (thrombin, adenosine diphosphate, serotonin and ionomycin). Despite… CONTINUE READING