Cytosolic and mitochondrial Ca2+ handling in pulmonary arterial smooth muscle and endothelial cells

@inproceedings{Stickel2017CytosolicAM,
  title={Cytosolic and mitochondrial Ca2+ handling in pulmonary arterial smooth muscle and endothelial cells},
  author={Diana Stickel},
  year={2017}
}
Cytosolic Ca elevated by receptor-operated (ROCE) or store operated Ca entry (SOCE) and buffered by mitochondrial Ca uptake plays an essential role in physiological processes of lung cells. Disturbed Ca homeostasis in precapillary pulmonary arterial smooth muscle cells (PPASMC) induces pulmonary arterial hypertension (PAH) or disrupts barrier function of murine pulmonary microvascular endothelial cells (MPMVEC) resulting in vascular leakage and lung edema. While SOCE is mediated by stromal… CONTINUE READING

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