Cytosolic and localized inhibition of phosphodiesterase by atrazine in swine tissue homogenates.

@article{Roberge2006CytosolicAL,
  title={Cytosolic and localized inhibition of phosphodiesterase by atrazine in swine tissue homogenates.},
  author={Mark T Roberge and Heldur Hakk and Gerald L Larsen},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2006},
  volume={44 6},
  pages={885-90}
}
Atrazine (ATR) significantly inhibited phosphodiesterase (PDE) in crude homogenates of swine heart, brain, and lung, but not liver or kidney tissues. Except for heart, PDE activities in the cytosolic fraction of the tissue homogenates were not affected by ATR. The inhibition of the PDE activity in the cytosol from heart homogenate was not significantly different between ATR and a non-specific PDE inhibitor, 3-isobutyl-1-methylxanthine (IBMX). Dixon plots of the crude tissue homogenates showed… CONTINUE READING

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