Cytosolic aggregates perturb the degradation of nontranslocated secretory and membrane proteins

Abstract

A wide range of diseases are associated with the accumulation of cytosolic protein aggregates. The effects of these aggregates on various aspects of normal cellular protein homeostasis remain to be determined. Here we find that cytosolic aggregates, without necessarily disrupting proteasome function, can markedly delay the normally rapid degradation of… (More)
DOI: 10.1091/mbc.E10-07-0638

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Cite this paper

@inproceedings{Chakrabarti2011CytosolicAP, title={Cytosolic aggregates perturb the degradation of nontranslocated secretory and membrane proteins}, author={Oishee Chakrabarti and Neena S. Rane and Ramanujan S Hegde}, booktitle={Molecular biology of the cell}, year={2011} }