Cytosolic adenylate kinases regulate K-ATP channel activity in human beta-cells.

Abstract

The role of adenylate kinase (AK) as a determinant of K-ATP channel activity in human pancreatic beta-cells was investigated. We have identified that two cytosolic isoforms of AK, AK1 and AK5 are expressed in human islets and INS-1 cells. Elevated concentrations of glucose inhibit AK1 expression and AK1 immunoprecipitates with the Kir6.2 subunit of K-ATP… (More)
DOI: 10.1016/j.bbrc.2008.01.109

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@article{Stanojevic2008CytosolicAK, title={Cytosolic adenylate kinases regulate K-ATP channel activity in human beta-cells.}, author={Violeta Stanojevic and Joel Francis Habener and George G. Holz and Colin A. Leech}, journal={Biochemical and biophysical research communications}, year={2008}, volume={368 3}, pages={614-9} }