Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin.

@article{Oleinikov2000CytosolicAP,
  title={Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin.},
  author={Andrew Oleinikov and J D Zhao and Sudesh Paul Makker},
  journal={The Biochemical journal},
  year={2000},
  volume={347 Pt 3},
  pages={
          613-21
        }
}
gp600/megalin, an endocytic receptor, belongs to the low-density lipoprotein receptor family. It is most abundant in the renal proximal tubular cells, where it is implicated in the reabsorption of a number of molecules filtered through the glomerulus. The cytoplasmic tail (CT) of gp600/megalin contains a number of sequence similarities, which indicate that gp600/megalin might be involved in signal transduction. To find intracellular proteins that would interact with the gp600/megalin CT, a… 
Megalin and cubilin: synergistic endocytic receptors in renal proximal tubule.
TLDR
The multiligand, endocytic receptors megalin and cubilin are colocalized in the renal proximal tubule and are important for normal tubular reabsorption of proteins, including albumin.
Identification of an apical sorting determinant in the cytoplasmic tail of megalin.
TLDR
It is concluded that the megalin-CT contains a novel apical sorting determinant and that cytoplasmic sorting machinery exists in MDCK cells for some apical transmembrane proteins.
Endocytosis of megalin by visceral endoderm cells requires the Dab2 adaptor protein
TLDR
It is suggested that Dab2 p96 mediates endocytosis of megalin in the VE, and rescue of embryonic viability correlates with endocybosis, suggesting that endocyTosis mediated by Dab 2 is important for normal development.
The Endocytic Receptor Megalin and its Associated Proteins in Proximal Tubule Epithelial Cells
TLDR
Evidence suggests that megalin and the cubilin-amnionless complex are involved in the uptake of toxic substances into PTECs, which leads to the development of kidney disease.
Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule
TLDR
Using yeast two-hybrid screens, a novel scaffold protein with tetratrico peptide repeats is identified, the megalin-binding protein (MegBP) that associates with the receptor and suggests a model whereby megal in directly participates in transcriptional regulation through controlled sequestration or release of transcription factors via MegBP.
New insights into the roles of megalin/LRP2 and the regulation of its functional expression.
TLDR
The expression of megalin and some of its ligands in the central and peripheral nervous system suggests a role for this receptor in neural regeneration processes, as well as the current understanding of the mechanisms that underlie the control ofmegalin expression.
Mutually dependent localization of megalin and Dab2 in the renal proximal tubule.
TLDR
The present study shows that Dab2 is localized in the apical endocytic apparatus of the renal proximal tubule and that this localization requires megalin, and suggests that the urinary loss of megal in ligands observed in Dab 2 knockout mice is caused by suboptimal trafficking of meGalin, leading to decreased megalIn levels.
Megalin and nonmuscle myosin heavy chain IIA interact with the adaptor protein Disabled-2 in proximal tubule cells.
TLDR
This study shows that NMHC-IIA is functionally linked to megalin by interaction with Dab2 and is likely involved in megal in-mediated endocytosis in proximal tubule cells.
The adaptor protein ARH escorts megalin to and through endosomes.
TLDR
Results show that ARH facilitates endocytosis of megal in, escorts megalin along its endocytic route and raise the possibility that transport through the endosomal system is selective and requires interaction with specific adaptor proteins.
A Cytoplasmic PPPSP Motif Determines Megalin's Phosphorylation and Regulates Receptor's Recycling and Surface Expression
TLDR
This work reports that the cytoplasmic domain of megalin is constitutively phosphorylated depending on the integrity of a PPPSP motif, a putative GSK3 site, with a minor participation of the other phosphorylation motifs.
...
1
2
3
4
5
...