Cytosolic T3-binding protein modulates dynamic alteration of T3-mediated gene expression in cells.

@article{Takeshige2014CytosolicTP,
  title={Cytosolic T3-binding protein modulates dynamic alteration of T3-mediated gene expression in cells.},
  author={Keiko Takeshige and Takashi Sekido and Jun-ichirou Kitahara and Yousuke Ohkubo and Dai Hiwatashi and Hiroaki Ishii and Shin-Ichi Nishio and Teiji Takeda and Mitsuhisa Komatsu and Satoru Suzuki},
  journal={Endocrine journal},
  year={2014},
  volume={61 6},
  pages={
          561-70
        }
}
μ-Crystallin (CRYM) is also known as NADPH-dependent cytosolic T3-binding protein. A study using CRYM-null mice suggested that CRYM stores triiodothyronine (T3) in tissues. We previously established CRYM-expressing cells derived from parental GH3 cells. To examine the precise regulation of T3-responsive genes in the presence of CRYM, we evaluated serial alterations of T3-responsive gene expression by changing pericellular T3 concentrations in the media. We estimated the constitutive expression… CONTINUE READING

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