Cytosolic Proteins Regulate α-Synuclein Dissociation from Presynaptic Membranes*

  title={Cytosolic Proteins Regulate α-Synuclein Dissociation from Presynaptic Membranes*},
  author={Sabine Wislet-Gendebien and Cheryl A. D’Souza and T. Kawarai and P. St. George-Hyslop and D. Westaway and P. Fraser and A. Tandon},
  journal={Journal of Biological Chemistry},
  pages={32148 - 32155}
  • Sabine Wislet-Gendebien, Cheryl A. D’Souza, +4 authors A. Tandon
  • Published 2006
  • Biology, Medicine
  • Journal of Biological Chemistry
  • Intracellular accumulation of insoluble α-synuclein in Lewy bodies is a key neuropathological trait of Parkinson disease (PD). Neither the normal function of α-synuclein nor the biochemical mechanisms that cause its deposition are understood, although both are likely influenced by the interaction of α-synuclein with vesicular membranes, either for a physiological role in vesicular trafficking or as a pathological seeding mechanism that exacerbates the propensity of α-synuclein to self-assemble… CONTINUE READING
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