Cytosolic PhospholipaseA2 Inhibition with PLA-695 Radiosensitizes Tumors in Lung Cancer Animal Models

@article{Thotala2013CytosolicPI,
  title={Cytosolic PhospholipaseA2 Inhibition with PLA-695 Radiosensitizes Tumors in Lung Cancer Animal Models},
  author={Dinesh Thotala and Jeffrey Craft and Daniel J Ferraro and Rama Prasadarao Kotipatruni and Sandeep R. Bhave and Jerry J. Jaboin and Dennis Hallahan},
  journal={PLoS ONE},
  year={2013},
  volume={8}
}
Lung cancer remains the leading cause of cancer deaths in the United States and the rest of the world. The advent of molecularly directed therapies holds promise for improvement in therapeutic efficacy. Cytosolic phospholipase A2 (cPLA2) is associated with tumor progression and radioresistance in mouse tumor models. Utilizing the cPLA2 specific inhibitor PLA-695, we determined if cPLA2 inhibition radiosensitizes non small cell lung cancer (NSCLC) cells and tumors. Treatment with PLA-695… 

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