Cytosolic Phospholipase A2 and Lysophospholipids in Tumor Angiogenesis

  title={Cytosolic Phospholipase A2 and Lysophospholipids in Tumor Angiogenesis},
  author={Amanda G. Linkous and Eugenia M. Yazlovitskaya and Dennis E. Hallahan},
  booktitle={Journal of the National Cancer Institute},
BACKGROUND Lung cancer and glioblastoma multiforme are highly angiogenic and, despite advances in treatment, remain resistant to therapy. Cytosolic phospholipase A2 (cPLA(2)) activation contributes to treatment resistance through transduction of prosurvival signals. We investigated cPLA(2) as a novel molecular target for antiangiogenesis therapy. METHODS Glioblastoma (GL261) and Lewis lung carcinoma (LLC) heterotopic tumor models were used to study the effects of cPLA(2) expression on tumor… CONTINUE READING