Cytosolic O-glycosylation is abundant in nerve terminals.

  title={Cytosolic O-glycosylation is abundant in nerve terminals.},
  author={Robert N Cole and Gerald W. Hart},
  journal={Journal of neurochemistry},
  volume={79 5},
Phosphorylation plays a key role in regulating growth cone migration and protein trafficking in nerve terminals. Here we show that nerve terminal proteins contain another abundant post-translational modification: beta-N-acetylglucosamine linked to hydroxyls of serines or threonines (O-GlcNAc(1)). O-GlcNAc modifications are essential for embryogenesis and mounting evidence suggests that O-GlcNAc is a regulatory modification that affects many phosphorylated proteins. We show that the activity and… CONTINUE READING
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