Cytosolic Ni(II) Sensor in Cyanobacterium

  title={Cytosolic Ni(II) Sensor in Cyanobacterium},
  author={Andrew W. Foster and Carl J. Patterson and Rafael Pernil and Corinna R Hess and Nigel J. Robinson},
  booktitle={The Journal of biological chemistry},
Efflux of surplus Ni(II) across the outer and inner membranes of Synechocystis PCC 6803 is mediated by the Nrs system under the control of a sensor of periplasmic Ni(II), NrsS. Here, we show that the product of ORF sll0176, which encodes a CsoR/RcnR-like protein now designated InrS (for internal nickel-responsive sensor), represses nrsD (NrsD is deduced to efflux Ni(II) across the inner membrane) from a cryptic promoter between the final two ORFs in the nrs operon. Transcripts initiated from… CONTINUE READING