Cytosolic Hsp90α and its mitochondrial isoform Trap1 are differentially required in a breast cancer model

@inproceedings{Vartholomaiou2017CytosolicHA,
  title={Cytosolic Hsp90α and its mitochondrial isoform Trap1 are differentially required in a breast cancer model},
  author={Evangelia Vartholomaiou and Marta Madon-Simon and St{\'e}phane Hagmann and Guillaume M{\"u}hlebach and Wolfgang Wurst and Thomas Floss and Didier Picard},
  booktitle={Oncotarget},
  year={2017}
}
The Hsp90 family of molecular chaperones includes the cytosolic isoforms Hsp90α and Hsp90β, and the mitochondrial isoform Trap1. Hsp90α/β support a large number of client proteins in the cytoplasm and the nucleus whereas Trap1 regulates oxidative phosphorylation in mitochondria. Many of the associated proteins and cellular processes are relevant to cancer, and there is ample pharmacological and genetic evidence to support the idea that Hsp90α/β and Trap1 are required for tumorigenesis. However… CONTINUE READING