Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity

  title={Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity},
  author={Y. Zhao and J. Yang and Wenjuan Liao and X. Liu and Hui Bin Zhang and S. Wang and Donglai Wang and J. Feng and L. Yu and W. Zhu},
  journal={Nature Cell Biology},
  • Y. Zhao, J. Yang, +7 authors W. Zhu
  • Published 2010
  • Biology, Medicine
  • Nature Cell Biology
  • Autophagy is characterized by the sequestration of bulk cytoplasm, including damaged proteins and organelles, and delivery of the cargo to lysosomes for degradation. Although the autophagic pathway is also linked to tumour suppression activity, the mechanism is not yet clear. Here we report that cytosolic FoxO1, a forkhead O family protein, is a mediator of autophagy. Endogenous FoxO1 was required for autophagy in human cancer cell lines in response to oxidative stress or serum starvation, but… CONTINUE READING
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