Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity

@article{Zhao2010CytosolicFI,
  title={Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity},
  author={Y. Zhao and J. Yang and Wenjuan Liao and X. Liu and Hui Bin Zhang and S. Wang and Donglai Wang and J. Feng and L. Yu and W. Zhu},
  journal={Nature Cell Biology},
  year={2010},
  volume={12},
  pages={665-675}
}
  • Y. Zhao, J. Yang, +7 authors W. Zhu
  • Published 2010
  • Biology, Medicine
  • Nature Cell Biology
  • Autophagy is characterized by the sequestration of bulk cytoplasm, including damaged proteins and organelles, and delivery of the cargo to lysosomes for degradation. Although the autophagic pathway is also linked to tumour suppression activity, the mechanism is not yet clear. Here we report that cytosolic FoxO1, a forkhead O family protein, is a mediator of autophagy. Endogenous FoxO1 was required for autophagy in human cancer cell lines in response to oxidative stress or serum starvation, but… CONTINUE READING
    410 Citations
    XBP-1u suppresses autophagy by promoting the degradation of FoxO1 in cancer cells
    • 79
    • PDF
    FoxO1-autophagy axis regulates lipid droplet growth via FSP27
    • 2
    Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells
    • 25
    • PDF
    Sirtuins' modulation of autophagy
    • F. Ng, B. Tang
    • Biology, Medicine
    • Journal of cellular physiology
    • 2013
    • 129
    Function and Molecular Mechanism of Acetylation in Autophagy Regulation
    • 184
    Tumor Suppression and Promotion by Autophagy
    • 104
    • PDF
    Histone Deacetylase Inhibitor-Induced Autophagy in Tumor Cells: Implications for p53
    • 15
    • Highly Influenced
    • PDF
    The role of autophagy in HER2-targeted therapy.
    • 4
    • PDF

    References

    SHOWING 1-10 OF 72 REFERENCES
    FoxO3 controls autophagy in skeletal muscle in vivo.
    • 1,506
    • PDF
    Induction of autophagy and inhibition of tumorigenesis by beclin 1
    • 2,888
    A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy
    • 1,009
    • PDF
    Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice
    • 1,967
    • PDF