Cytosol induces apparent selectivity of glucocorticoid receptor binding to nucleic acids of different secondary structure.

Abstract

Unpurified rat liver glucocorticoid-receptor complexes within cytosol show a distinct binding preference for double-stranded DNA over single-stranded DNA; the binding to Escherichia coli rRNA is negligible. Extensive purification of the receptor abolishes its ability to distinguish among DNAs of different secondary structure and the affinity of the purified… (More)

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